Aliaga Vidal Carolina

Email: 
carolina.aliaga@usach.cl
Teléfono: 
27 181 131
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=CAROLINA%20D.P.%20ALIAGA%…
Abstract

We develop a novel series of pre-fluorescent compounds based on pyridinium salts with different hydrophobicity and spectral behavior attached to a nitroxyl moiety. 
The activity of these new probes are monitored by fluorescence and/or EPR spectroscopy.
We also investigate the importance of the distribution of the probe and substrate in microheterogeneous media in hydrogen-transfer reactions. We are interested in to study the distribution of these compounds depending on their hydrophobicities, an aspect which has been systematically ignored in previous evaluations of antioxidant activities. By employing a series of nitroxide derivatives and probes of variable hydrophobicities  we will be able to measure these effects in a systematic way. We hope to arrive at a more rigorous model for medium effects on hydrogen-transfer processes.
We also investigate the hydrogen transfer process by directly monitoring nitroxides with phenols with different hydrophobicities by employing electronic spin resonance techniques.

Línea(s) de investigación: 
Reactividad y Cinética de Reacciones de Radicales Libres con especies donoras de Hidrogeno. Caracterización de especies radicales Orgánicas e Inorgánicas.
Jerarquía: 
Investigador Asociado, Vicerrectoria de Investigación y Desarrollo.
Grados académicos /educación: 
Profesora de Química y Ciencias Naturales
Doctora en Química
Publicaciones: 
  • C. Aliaga, F. Bravo-Moraga, D. Gonzalez-Nilo, S. Márquez, S. Lühr, G. Mena, M. C. Rezende. “Location of TEMPO derivatives in micelles: subtle effect of the probe orientation” Food Chemistry, (2016), 192, 395-401.
  • C. Aliaga, F. Celis, S. Lühr, R. Oñate “TEMPO-Attached Pre-fluorescent Probes Based on Pyridinium Fluorophores” J. Fluorescence (2015) 25, 979-983.
  • C. Aliaga, I. Almodovar and M. C. Rezende “A single theoretical descriptor for the bond-dissociation energy of substituted phenols” J Mol Model (2015) 21: 12 DOI 10.1007/s00894-015-2572-x.
  • A. B. Oliveira, R. L. Rodriguez-Suarez, S. Michea, H. Vega, A. Azevedo, S. M. Rezende, C. Aliaga, and J. Denardin. “Angular dependence of hysteresis shift in oblique deposited ferromagnetic/antiferromagnetic coupled bilayers” Journal of Applied Physics 116 (2014) 033910. doi: 10.1063/1.4890457.
  • M.C. Rezende, I. Ponce, R. Oñate. I. Almodóvar, C. Aliaga. Change Of Mechanism With A Change Of Substituents For A Zincke Reaction Tetrahedron Letters 55 (2014) 3097–3099.
  • C. Aliaga*, M.C. Rezende, “EPR spectrum of a radical from a non typical antioxidant”, Magn. Resn. Chem. 52, (2014) 409–411 DOI: 10.1002/mrc.4070
  • C. Aliaga*, P.Fuentealba, M. C Rezende, C. Cárdenas “Mechanism of fluorophore quenching in a pre-fluorescent nitroxide probe: a theoretical illustration.” Chem. Phys. Lett. 593 (2014) 89–92.
  • R.L. Rodríguez-Suárez, J.L. Palma, E.O. Burgos, S. Michea, J. Escrig, J.C. Denardin, C. Aliaga. “Ferromagnetic resonance investigation in permalloy magnetic antidot arrays on alumina nanoporous membranes” J. Magnetism Magnetic Mat, 350 (2014) 88-93.
  • E. I. Alarcon, A. Aspee, C. Aliaga S. E. Braslavsky, “Special Issue Dedicated to the Memory of Elsa Beatriz Abuin Saccomano (1942–2012)” Photochem. Photobiol., 89 (2013) 1270–1272.
  • C. Aliaga, P.Torres and F. Silva. “A simple method for the determination of the partitioning of nitroxide probes in microheterogeneous media” Magn. Resn. Chem., 50 (2012) 779-783
  • D. Venegas-Yazigi, K. Brown, A. Vega, R. Calvo, C. Aliaga, R. Santana, R. Cardoso-Gil, R. Kniep, W. Schnelle, E. Spodine. "Exchange Interactions Through π-π Stacking in the Lamellar Compound [{Cu(bipy)(en)}{Cu(bipy)(H2O)}{VO3}4]n" Inorganic Chemistry. 50 (2011) 11461–11471.
  • M. C. Rezende, C. Mascayano, L. Briones, C. Aliaga. “Sensing different micellar microenvironments with solvatochromic dyes of variable lipophilicity” Dyes and Pigment, 90 (2011) 219-224
  • R. Bridi, C. Aliaga, A. Aspee, E. Abuin, and E. A. Lissi. “Distribution and reactivity of gallates toward galvinoxyl radicals in SDS micellar solutions. Effect of the alkyl chain length” Can. J. Chem. 89, (2011) 181-185.
  • C. Aliaga, L. Briones, M.C. Rezende, C. Tirapegui. “The thermochromism of the ET(30) betaine in a micro-heterogeneous medium: a spectral and dynamics simulation study” J. Coll. Int. Sci., 349 (2010) 565–570.
  • D. Venegas-Yazigi, K. Muñoz-Becerra, E. Spodine, K. Brown, C. Aliaga, V. Paredes-García, P. Aguirre, A. Vega, R. Cardoso-Gil, W. Schnelle, R. Kniep. Magnetic and Catalytic Properties of the 2D Copper (II) Functionalized VPO Hybrid System [{Cu(bpy)}2(VO)3(PO4)2(HPO4)2]·2H2O, Polyhedron 29 (2010) 2426-2434
  • C. Aliaga*, M.C. Rezende and C. Tirapegui “A new probe for hydrogen abstraction and radical detection” Tetrahedron 65 (2009) 6025–6028.

 

Proyectos: 

Investigador responsable

  1. FONDECYT  1110736 “Design and properties of new prefluorescent probes in homo and microhetero-geneous media”, 2011-2014
  2. FONDECYT 1080234 “Use of prefluorescent and radical probes for the study of medium effects on hydrogen transfer reactions”, 2008-2010
  3. DICYT- USACH “Detección de especies radicalarias por técnicas de resonancia de espín electrónico (ESR) en sistemas de interés biológico”. USACH, 2006-2007
  4. Inserción de Investigadores/as postdoctorales -World Bank. Microscopías y Espectroscopías. USACH-CONICYT, 2005-2007

Co-Investigador

 

  1. FONDECYT (1140212) "Perichromic dyes in homogeneous media and adsorbed on nanoparticles", 2014 - 2018
  2. Proyecto FONDEF (PROGRAMA IDeA De FONDEF‐CONICYT ) CA12i10116 Determinación de dosis de radiación aplicada  a alimentos por Resonancia de Spin Electrónico (ESR ), 2012-2015.
  3. Proyecto Basal-CONICYT FB0807, Centro para el Desarrollo de la Nanociencia y la Nanotecnología, CEDENNA (Investigador Asociado, Linea 4) 2009-201

Investigador Asociado

  1. DICYT 021541ª, USACH. Anillo. “Inorganic Polyfunctional Materials Based on Chilean Strategic Metals. IPMaG". 2015 - 2017

PROGRAMA DE INVESTIGACION ASOCIATIVA. CONICYT, Anillo "Inorganic Polyfunctional Materials Based on Chilean Strategic Metals. IPMaG", 2015 - 2017. 

Otras actividades relevantes: 

Número de tesis dirigidas en los últimos 10 años:

Doctorado:       Dirigidas: 1             En desarrollo:             1

 

Referee de revistas internacionales

  1. Photochemistry and Photobiology 
  2. Food Chemistry

 

Revisor de proyectos

  1. FONDECYT Regulares
  2. FONDECYT Posdoctoral
  3. FONDECYT Iniciación
  4. FONDEQUIP
  5. DICYT

Par evaluador de Postgrado

  • Programa de Doctorado en Química, Universidad de Chile

 

Comité de sociedades científicas

  1. Miembro de la Royal Society of Chemistry
  2. Miembro de la Photochemistry and Photobiology Society

 

Participación en claustro de doctorados

  • Doctorado en Química